What are the Signs and
Symptoms of SJIA?

Systemic Juvenile Idiopathic Arthritis (SJIA) attacks are commonly referred to as flares. The signs and symptoms that accompany an SJIA flare can resemble those of other common diseases, making it hard to diagnose. If you think your child may have SJIA, a pediatric rheumatologist may help in diagnosing and treating your child.

Your child's doctor will find it helpful if you track daily symptoms in order to properly diagnose SJIA. So it's very important to monitor your child's fevers. You can use the SJIA symptom tracker to keep track of all of your child's signs and symptoms, which may include:

Fever

Recurring fever is the most common symptom of SJIA. Fevers can reach temperatures of 102 degrees or higher, before falling within a couple of hours. Many people with SJIA experience a daily spike in fevers, which doctors may refer to as quotidian fevers. You may also notice your child's fever follows a pattern.

Rash

Rash is another common symptom of SJIA. SJIA rashes are usually made up of small spots that are a pale red or salmon color. Rashes often occur on the chest, upper arms, and upper thighs. Usually, the rash does not itch. In addition to using the symptom tracker to record your child's symptoms, it's also a good idea to take photos of his or her rash. Make sure to bring the tracker with you to your child's doctor appointment.

Patient with SJIA rash.

Swollen Joints

The knees, wrists, and ankles are the joints most likely to be affected in a child with SJIA. Joints become painful, stiff, and swollen, and more than one joint is usually involved at a time. These symptoms can be mild one day and severe the next.

Pain

Children may fail to communicate their pain, and some begin experiencing this pain so early in life that they actually think their pain is normal. It is important to notice when your child is hurting.

This can be a challenge, especially if your child cannot explain things very well yet. Check for crying, facial expressions, agitation, and level of ability to be consoled. You can also keep track of all of your child's signs and symptoms by using the symptom tracker.

Only a physician can diagnose SJIA, so be sure to talk to a doctor
about all of the signs and symptoms that your child is experiencing.

Speak to a rheumatologist online today

The road to diagnosis can be challenging, but you can get help on the path to finding answers. You can talk to a rheumatologist with experience in auto-inflammatory diseases from the comfort of your home. To get started, we will connect you to an independent third-party company website.

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IMPORTANT SAFETY INFORMATION

ILARIS can cause serious side effects, including increased risk of serious infections. ILARIS can lower the ability of your immune system to fight infections. Your healthcare provider should:

test you for tuberculosis (TB) before you receive ILARIS.
monitor you closely for symptoms of TB during treatment with ILARIS
check you for symptoms of any type of infection before, during, and after treatment with ILARIS

Tell your healthcare provider right away if you have any symptoms of an infection such as fever, sweats or chills, cough, flu-like symptoms, weight loss, shortness of breath, blood in your phlegm, sores on your body, warm or painful areas on your body, diarrhea or stomach pain, or feeling very tired.

You should not receive ILARIS if you are allergic to canakinumab or any of the ingredients in ILARIS.

Before receiving ILARIS, tell your healthcare provider about all your medical conditions, including if you:

think you have or are being treated for an active infection.
have symptoms of infection.
have a history of infections that keep coming back.
have a history of low white blood cells.
have or have had HIV, Hepatitis B, or Hepatitis C.
are scheduled to receive any immunizations (vaccines). You should not get 'live vaccines' if you are receiving ILARIS.
are pregnant or planning to become pregnant. It is not known if ILARIS will harm your unborn baby. Tell your healthcare provider right away if you become pregnant while receiving ILARIS.
received canakinumab while you were pregnant. It is important that you tell your baby's healthcare provider before any vaccincations are given to your baby within 4-12 months after you received your last dose of canakinumab before giving birth
are breastfeeding or planning to breastfeed. It is not known if ILARIS passes into your breast milk. Talk to your healthcare provider about the best way to feed your baby if you receive ILARIS.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Especially tell your healthcare provider if you take:

medicines that affect the immune system.
medicines called interleukin-1 (IL-1) blocking agents such as Kineret^® (anakinra) or Arcalyst^® (rilonacept).
medicines called Tumor Necrosis Factor (TNF) inhibitors such as Enbrel^® (etanercept), Humira^® (adalimumab), Remicade^® (infliximab), Simponi^® (golimumab), or Cimzia^® (certolizumab pegol).
medicines that affect enzyme metabolism.

Ask your healthcare provider for a list of these medicines if you are not sure.

ILARIS can cause serious side effects including:

serious infections
decreased ability of your body to fight infections (immunosuppression). For people treated with medicines that cause immunosuppression like ILARIS, the chances of getting cancer may increase
allergic reactions. Allergic reactions can happen while receiving ILARIS. Call your healthcare provider right away if you have any of these symptoms of an allergic reaction: difficulty breathing or swallowing, nausea, dizziness or feeling faint, rash, itching or hives, palpitations (feels like your heart is racing), or low blood pressure
risk of infection with live vaccines. You should not get live vaccines if you are receiving ILARIS. Tell your healthcare provider if you are scheduled to receive any vaccines.

The most common side effects of ILARIS when used for treatment of Still's disease (AOSD and SJIA) include: cold symptoms, upper respiratory tract infection, pneumonia, runny nose, sore throat, urinary tract infection, nausea, vomiting and diarrhea (gastroenteritis), stomach pain, and injection site reactions (such as redness, swelling, warmth, or itching).

Tell your healthcare provider about any side effect that bothers you or does not go away.

What is Macrophage Activation Syndrome (MAS)?

MAS is a syndrome associated with Still's disease and some other auto-inflammatory diseases like HIDS/MKD that can lead to death. Tell your healthcare provider right away if your AOSD or SJIA symptoms get worse or if you have any of these symptoms of an infection:

a fever lasting longer than 3 days.
a cough that does not go away.
redness in one part of your body.
warm feeling or swelling of your skin.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

Please see full Prescribing Information, including Medication Guide.

APPROVED USE

ILARIS^® (canakinumab) is a prescription medicine injected by your healthcare provider just below the skin (subcutaneous) used to treat Still's disease including Adult-Onset Still's Disease (AOSD) and Systemic Juvenile Idiopathic Arthritis (SJIA) in children 2 years of age and older.

It is not known if ILARIS is safe and effective when used to treat SJIA in children under 2 years of age.

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What are the Signs and Symptoms of SJIA?

Fever

Rash

Swollen Joints

Pain

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What are the Signs and
Symptoms of SJIA?