Dosing for ILARIS to Treat Active SJIA

Dosing for ILARIS to Treat FMF
Dosing for ILARIS to Treat FMF

A once-monthly injection

ILARIS is not given as an intravenous infusion (infused inside a vein over time); it is given as a subcutaneous injection (right under the skin) every 4 weeks by a doctor or nurse.

At your doctor's request, Novartis can send a home health nurse to your home to give your child his or her monthly ILARIS injection.

How Does ILARIS Work?

To understand how ILARIS works, it's important to start with the role of the immune system in Systemic Juvenile Idiopathic Arthritis (SJIA) and how inflammation (the body's way of protecting itself against sickness or injury) gets triggered in the body.

Inflammation with SJIA

Inflammation with SJIA

Inflammation with SJIA

Inflammation with SJIA

ILARIS targets an important cause of SJIA symptoms

ILARIS targets an important cause of SJIA symptoms

  • For children with SJIA, the immune system (the body's natural defense system that protects against "foreign" invaders) produces too much of a substance called a cytokine

  • Too much of a cytokine called interleukin-1 beta (IL-1) is an important cause of inflammation in SJIA. When IL-1 attaches to interleukin-1 receptors (IL-1R), the immune system triggers inflammation

  • For children with SJIA, the immune system triggers inflammation even when there's no infection to fight. This can cause recurring SJIA symptoms, like fever and swollen and/or painful joints

SJIA Treatment with ILARIS

SJIA Treatment with ILARIS

SJIA Treatment with ILARIS

SJIA Treatment with ILARIS

ILARIS targets IL-1 to help reduce inflammation

ILARIS targets IL-1 to help reduce inflammation

  • ILARIS is a different kind of treatment for SJIA. It's a biologic medicine, which means it's designed to target a specific source of inflammation. ILARIS targets IL-1

  • By attaching to IL-1, ILARIS helps to block its interaction with IL-1R

  • This action helps to stop the immune system from triggering inflammation

If your child is diagnosed with SJIA, ask a doctor whether ILARIS may be right for your child.

Next: Talking to a Doctor