Dosing for ILARIS to Treat HIDS/MKD

Dosing for ILARIS to Treat HIDS/MKD
Dosing for ILARIS to Treat HIDS/MKD

A once-monthly injection

ILARIS® is not given as an intravenous infusion (infused inside a vein over time); it is given as a subcutaneous injection (right under the skin) once a month by a doctor or nurse.

At your doctor's request, Novartis can send a home health nurse to your home to give your child his or her monthly ILARIS injection.

How Does ILARIS Work?

To understand how ILARIS works, it's important to start with the role of the immune system in Hyperimmunoglobulin D Syndrome / Mevalonate Kinase Deficiency (HIDS/MKD), and how inflammation gets triggered in the body.

Inflammation with HIDS/MKD

Inflammation with HIDS/MKD

Inflammation with HIDS/MKD

Inflammation with HIDS/MKD

ILARIS targets an important cause of HIDS/MKD symptoms

  • For children with HIDS/MKD, the immune system (the body's natural defense system that protects against “foreign” invaders) produces too much of a substance called a cytokine

  • Too much of a cytokine called interleukin-1 beta (IL-1) is an important cause of inflammation in HIDS/MKD. When IL-1 attaches to interleukin-1 receptors (IL-1R), the immune system triggers inflammation

  • For children with HIDS/MKD, the immune system triggers inflammation even when there's no infection to fight. This can cause recurring HIDS/MKD symptoms, like fever and swollen and/or painful joints

Treatment with ILARIS

Treatment with ILARIS

Treatment with ILARIS

Treatment with ILARIS

ILARIS targets IL-1 to help reduce inflammation

ILARIS targets IL-1 to help reduce inflammation

  • ILARIS is a different kind of treatment for HIDS/MKD. It's a biologic medicine, which means it's designed to target a specific source of inflammation. ILARIS targets IL-1

  • By attaching to IL-1, ILARIS helps to block its interaction with IL-1R

  • This action helps to stop the immune system from triggering inflammation

If your child is diagnosed with HIDS/MKD, ask a doctor about whether ILARIS may be right for your child.

Next: Talking to a Doctor