Answers to Your Questions About FMF and ILARIS

Answers to Your Questions About FMF and ILARIS

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What is Familial Mediterranean Fever (FMF)?

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FMF is an inherited, rare, and serious condition belonging to a group of diseases called Periodic Fever Syndromes. Like other types of Periodic Fevers, FMF is an autoinflammatory condition that can cause attacks, or flares, which can result in symptoms such as fever, stomach pain, rash, chest pain, and muscle/joint pain.

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What causes FMF?

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FMF is a genetic disease caused by an inherited mutation of the MEFV gene, which causes an overactivation of a protein called cryopyrin. This leads to an overproduction of interleukin-1 beta (IL-1β), a protein that is part of the body's immune system. Too much IL-1β in the body can lead to inflammation and other symptoms of FMF.

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How long will my child have FMF?

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There is no cure for FMF, but with continuous treatment, children with FMF may experience symptom improvement.

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What are Periodic Fever Syndromes?

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Periodic Fever Syndromes are a group of rare, autoinflammatory diseases that are characterized by symptoms including recurrent fevers, rash, pain, and joint inflammation. Periodic Fevers are typically inherited from other family members, but can occur on their own. Both children and adults can be affected by Periodic Fevers, though symptoms usually begin during childhood.

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Is FMF contagious?

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FMF is not contagious. It's an inherited disease, which means that it can be passed down from other family members, although the disease can occur on its own. Certain factors are thought to trigger FMF flares, including stress, immunizations, and intense physical activity.

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What will happen to my child with FMF?

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FMF can vary from child to child. In some patients, untreated FMF can lead to a buildup of protein in the kidneys, which can lead to kidney damage and/or failure. So you should keep track of your child's FMF symptoms, and be sure to know about possible disease triggers. Learn about Managing FMF.

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What is ILARIS?

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ILARIS® is a prescription medication that is FDA approved to treat FMF. ILARIS works by attaching to and blocking interleukin-1 beta (IL-1β), a type of cytokine responsible for inflammation. ILARIS is given once a month as a subcutaneous injection right below the skin.

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How can ILARIS help with FMF?

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ILARIS helps provide fast and sustained relief. Of 31 study participants with FMF, 61.3% of FMF patients had minimal to no disease activity at Day 15 through Week 16 of the study. Study participants were assessed and given a single Physician's Global Assessment (PGA) score based on several signs and symptoms, including chest pain, abdominal pain, arthralgia/arthritis (painful and/or swollen joints), and skin rash.

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Is ILARIS given intravenously?

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ILARIS is not given as an intravenous infusion (infused inside a vein over a period of time). Instead, it is given as a subcutaneous (right under the skin) injection, or shot, once a month by a doctor or nurse. A home health nurse can be sent to your home to administer ILARIS to your child. If you are eligible, this service and other ILARIS support opportunities may be available for your child.

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How often will my child receive ILARIS?

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ILARIS is given as a once-monthly injection. A home health nurse can be sent to your home to administer ILARIS to your child. If you are eligible, this service and other ILARIS support opportunities may be available for your child.

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Is support available to help us pay for ILARIS?

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We're committed to helping you get access to ILARIS. Our representatives work with you and your child's doctor to help you get started, including:

  • Contacting your insurance company

  • Verifying insurance benefits and investigation of coverage

  • Addressing coverage issues

  • Assisting with prior authorization and appeals, if needed

  • Providing co-pay* assistance for eligible patients with commercial insurance

  • Providing information about alternative assistance options for uninsured patients

*Limitations apply. Please contact the ILARIS Support Program at 866-972-8315 for more information.

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Who can I speak to if I have more questions about ILARIS?

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Talk to your child's pediatric rheumatologist or other healthcare professional. Your child's active FMF treatment team can consist of many important members. Make sure that you find a doctor that you and your child are both comfortable with.

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