Dosing for ILARIS to Treat CAPS

Dosing for ILARIS to Treat FMF
Dosing for ILARIS to Treat FMF

ILARIS® is not given as an intravenous infusion (infused inside a vein over time); it is given as a subcutaneous injection (right under the skin) by a doctor or nurse once every 8 weeks—just 6 or 7 treatments in a year.

At your doctor's request, Novartis can send a home health nurse to your home to give your child his or her monthly ILARIS injection.

How Does ILARIS Work?

To understand how ILARIS works, it's important to start with the role of the immune system in Cryopyrin-Associated Periodic Syndromes (CAPS) and how inflammation (the body's way of protecting itself against sickness or injury) gets triggered in the body.

Inflammation with CAPS

Inflammation with CAPS

Inflammation with CAPS

Inflammation with CAPS

ILARIS targets an important cause of CAPS symptoms

  • For children and adults with CAPS, the immune system (the body's natural defense system that protects against "foreign" invaders) produces too much of a substance called a cytokine

  • Too much of a cytokine called interleukin-1 beta (IL-1) is an important cause of inflammation in CAPS. When IL-1 attaches to interleukin-1 receptors (IL-1R), the immune system triggers inflammation

  • For children and adults with CAPS, the immune system triggers inflammation even when there's no infection to fight. This can cause recurring CAPS symptoms, like rash and painful joints and/or muscles

CAPS Treatment with ILARIS

Treatment with ILARIS

CAPS Treatment with ILARIS

Treatment with ILARIS

ILARIS targets IL-1 to help reduce inflammation

  • ILARIS is a different kind of treatment for CAPS. It's a biologic medicine, which means it's designed to target a specific source of inflammation. ILARIS targets IL-1

  • By attaching to IL-1, ILARIS helps to block its interaction with IL-1R

  • This action helps to stop the immune system from triggering inflammation

If your child is diagnosed with CAPS, ask a doctor whether ILARIS may be right for your child.

Next: Talking to a Doctor