Glossary

A – Z

Z – A

Print CAPS glossary terms
  • Autoinflammatory disease:

    an illness in which the body's control of inflammation is not functioning properly, leading to uncontrolled inflammation.

  • Biologic:

    a product made from living cells that is used to treat diseases.

  • Cryopyrin:

    a specific type of protein produced by the NLRP3 gene that is found in the fluid of white blood cells and cartilage-forming cells.

  • Cryopyrin-Associated Periodic Syndromes:

    a group of rare and genetic diseases that includes Familial Cold Autoinflammatory Syndrome (FCAS) and Muckle-Wells Syndrome (MWS).

  • Cytokine:

    a protein produced by the body that interacts with the cells of the immune system to help fight infection. When the body produces too much of a cytokine, it can cause inflammation and tissue destruction.

  • Disease:

    a condition of a body part, organ, or system that occurs due to genetics, infection, or the environment and that typically presents with a specific group of symptoms.

  • Familial Cold Autoinflammatory Syndrome:

    an autoinflammatory disease in a group of rare diseases called Cryopyrin-Associated Periodic Syndromes (CAPS). It is also known as FCAS.

  • Flare:

    the worsening and increase in severity of disease symptoms.

  • Genetic:

    of or relating to the genes or heredity, meaning it can be passed down in families.

  • Immune system:

    the body's natural defense system that protects against any material foreign to the body.

  • Inflammation:

    the body's way of protecting itself against infection or injury. When someone has the condition called Cryopyrin-Associated Periodic Syndromes (CAPS), inflammation occurs without infection or injury.

  • Injection:

    usually referred to as "a shot," an injection puts medication into the body using a syringe.

  • Interleukin-1 beta (IL-1β):

    a protein that the immune system produces to fight disease with inflammation. The production of too much IL-1β is harmful to the body.

  • Muckle-Wells Syndrome:

    an autoinflammatory disease in a group of rare diseases called Cryopyrin-Associated Periodic Syndromes (CAPS). It is also known as MWS.

  • Pediatric Rheumatologist:

    a doctor who specializes in treating children and adolescents with rheumatic diseases, including arthritis, many autoimmune diseases, and many autoinflammatory diseases.

  • Periodic Fever Syndromes:

    a group of rare, autoinflammatory diseases that are characterized by symptoms including recurrent fevers, rash, pain, and joint inflammation.

  • Rare disease:

    an uncommon illness that affects very few people.

  • Symptoms:

    a description of the way you are feeling due to an illness.