How Does ILARIS Work?

How ILARIS Works

How SJIA Treatment Works
  • For a child with SJIA, the immune system (the body's natural defense system that protects against "foreign" invaders) produces too much of a substance called a cytokine
  • Too much of a cytokine called interleukin 1 beta (IL-1β) is an important cause of inflammation in SJIA. When IL-1β attaches to interleukin-1 receptors (IL-1R), the immune system triggers inflammation
  • For those with SJIA, the immune system triggers inflammation even when there's no infection to fight. This causes recurring SJIA symptoms like fever and swollen and/or painful joints

ILARIS targets IL-1β to help reduce inflammation

How SJIA Treatment Works
  • ILARIS is a different kind of treatment for SJIA. It's a biologic medicine, which means it's designed to target a specific source of inflammation. ILARIS targets IL-1β
  • By attaching to IL-1β, ILARIS helps to block its interaction with IL-1R
  • This action helps to stop the immune system from triggering inflammation