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Symptoms: a description of the way you are feeling due to an illness.
Arthritis: inflammation of one or more joints, which can cause pain, swelling, stiffness, and loss of motion.
Inflammation: the body's protective response that results in heat, pain, redness, and swelling.
Juvenile Arthritis (JA): a medical condition that occurs in children before age 16 and involves swelling in one or more joints lasting at least 6 weeks.
Systemic Juvenile Idiopathic Arthritis (SJIA): a type of arthritis that has no apparent cause and affects children aged 16 years and younger. Like other forms of juvenile idiopathic arthritis, SJIA involves swelling in one or more joints lasting at least 6 weeks. However, SJIA affects the whole body, beyond the joints. It is characterized by spiking fevers that come and go and a pink or salmon-colored rash, both of which may precede swollen joints.
Idiopathic: the exact cause of the disease is unknown.
Autoinflammatory disease: an illness in which the body's control of inflammation is not functioning properly, leading to uncontrolled inflammation.
Pediatric rheumatologist: a doctor who specializes in diagnosing and treating bone and joint disorders in children and teenagers.
Systemic: affecting the entire body, rather than a single organ or body part.
Flare: the worsening and increase in severity of disease symptoms.
Biologic: a product made from living cells that is used to treat diseases. Biologics are genetically engineered proteins derived from human genes.
Cytokine: a protein produced by the body that interacts with the cells of the immune system to help fight infection. When the body produces too many cytokines, it can cause inflammation and tissue destruction.
Injection: usually referred to as "a shot," an injection puts medication into the body using a syringe.
Cryopyrin-Associated Periodic Syndromes: a group of rare and genetic diseases that includes Familial Cold Autoinflammatory Syndrome (FCAS) and Muckle-Wells Syndrome (MWS).
Genetic: of or relating to the genes or heredity, meaning it can be passed down in families.
Disease: a condition of a body part, organ, or system that occurs due to genetics, infection, or the environment and that typically presents with a specific group of symptoms.
Familial Cold Autoinflammatory Syndrome: an autoinflammatory disease in a group of rare diseases called Cryopyrin-Associated Periodic Syndromes (CAPS). It is also known as FCAS.
Inflammation: the body's way of protecting itself against infection or injury. When someone has the condition called Cryopyrin-Associated Periodic Syndromes (CAPS), inflammation occurs without infection or injury.
IL-1β: a protein that the immune system produces to fight disease with inflammation. The production of too much IL-1▀ is harmful to the body. IL-1β is also called interleukin-1 beta.
Immune system: the body's natural defense system that protects against any material foreign to the body.
Muckle-Wells Syndrome: an autoinflammatory disease in a group of rare diseases called Cryopyrin-Associated Periodic Syndromes (CAPS). It is also known as MWS.
Rare disease: an uncommon illness that affects very few people.
Conjunctivitis: Also called pink eye, conjunctivitis is redness and inflammation of the whites of the eyes and eyelids. There are many causes of conjunctivitis, including Familial Cold Autoinflammatory Syndrome and Muckle-Wells Syndrome.